Predictive Risks of Pre-eclampsia and Cardiovascular Diseases in Mild, Moderate and Severe Hypertensive Pregnant Women

Authors

  • Ogbonnia Ekuma-Okereke Department of Medical Laboratory Science, Faculty of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria
  • C.E Dioka Department of Chemical Pathology, College of Medicine, Nnamdi Azikiwe University, Nnewi campus, Anambra State, Nigeria
  • Ignatius C. Maduka Department of Human Biochemistry, Nnamdi Azikiwe University, Nnewi campus, Anambra state, Nigeria
  • Rose N. Ukibe 2Department of Medical Laboratory Science, Faculty of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria
  • Patrick Onochie Manafa Department of Medical Laboratory Science, Faculty of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria
  • Innocent S. Ogbu Department of Medical Laboratory Science, Faculty of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria

Keywords:

Pre-eclampsia, Hypertension, Pregnancy, Thyroid function, inflammatory reaction

Abstract

Background: Gestational hypertension (GH), is a condition characterized by high blood pressure during pregnancy with proteinuria ? 15 mg/dl and can lead to serious complications such as pre-eclampsia, eclampsia and cardiovascular diseases if not managed properly.

Objectives: This study was designed to evaluate the factors predisposing mild, moderate and/or severe GH to pre-eclampsia and cardiovascular risks using thyroid function and the serum activity of C-reactive protein (CRP) in hypertensive and normotensive pregnant women.

Method: A total of 150 diagnosed hypertensive pregnant women classified into 43 mild, 58 moderate and 49 severe GH and 150 normotensive individuals serving as control were carefully selected for this study.The serum levels of thyroid stimulating hormone (TSH), free tri-iodothyronine (FT3), free thyroxine (FT4) and CRP were measured using enzyme linked immuno-sorbent (ELISA) assay procedure.

Result: The mean values of TSH and CRP were significantly higher (P<0.05) in hypertensive subjects (3.9±3.1 and 23.9±9.7) when compared with the control (2.0±1.1 and 5.5±2.1) respectively. The mean level of FT3 was significantly decreased in hypertensive subjects (3.2±2.0) when compared with the control subjects (5.1±2.3) (P<0.05). Furthermore, the serum levels of TSH and CRP were significantly elevated (P<0.05) as the severity of gestational hypertension became increased (mild (3.1±2.8 and 12.6±9.8); moderate (3.8±2.7 and 18.7±8.9); and severe (4.5±3.5 and 25.9±10.9) respectively. Also, the serum level of TSH correlated positively with the serum level of CRP (r = 0.122, P = 0.000), and negatively correlated with FT3 and FT4 (r = -0.595, P = 0.000 and r = -0.365, P = 0.000) respectively.

Conclusion: We observed that serum elevations of CRP and TSH (in the presence of significantly reduced metabolically active thyroid-hormonal agent (FT3) are consistently associated with the progression of gestational hypertension. Therefore, could be used as predictive markers for the occurrence of pre-eclampsia and cardiovascular diseases which are complications often associated with poorly managed mild, moderate and/or severe gestational hypertension.

 

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Published

2021-07-20

How to Cite

Ekuma-Okereke, O., Dioka , C., Maduka , I. C., Ukibe , R. N., Manafa, . P. O., & Ogbu, I. S. (2021). Predictive Risks of Pre-eclampsia and Cardiovascular Diseases in Mild, Moderate and Severe Hypertensive Pregnant Women. Journal of Current Biomedical Research, 1(1), 29–38. Retrieved from https://journals.unizik.edu.ng/jcbr/article/view/711

Issue

Vol. 1 No. 1 (2017): Journal of current Biomedical Research

Section

Articles