TY - JOUR AU - Okokon, Jude E. AU - Bassey, Augustine IL AU - Udom, Godswill J. AU - Edem, Utibe A. AU - Attah, Godwin PY - 2022/04/30 Y2 - 2024/03/29 TI - ALPHA AMYLASE AND ALPHA GLUCOSIDASE INHIBITORY ACTIVITIES OF Croton zambesicus LEAF FRACTIONS IN WISTAR RATS JF - Journal of Current Biomedical Research JA - jcbr VL - 2 IS - 2, Mar-April SE - Articles DO - 10.54117/jcbr.v2i2.10 UR - https://journals.unizik.edu.ng/jcbr/article/view/1028 SP - 145-157 AB - <p><em>Croton zambesicus </em>Muell Arg. (Euphorbiaceace) a medicinal plant used traditionally in the treatment of diseases including diabetes was evaluated for effect on alpha amylase and alpha glucosidase enzymes <em>in vivo</em>. The leaf fractions (hexane, dichloromethane, ethyl acetate, methanol, 150 mg/kg) of <em>C. zambesicus </em>were investigated <em>in vivo</em> for inhibitory effect on alpha amylase and alpha glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug. The leaf fractions (n-hexane, DCM and ethyl acetate) caused significant (p&lt;0.05) reduction in blood glucose levels of treated rats with the various substrates used. DCM fraction exerted the highest inhibitory effect when starch was used as substrate followed by <em>n</em>-hexane. <em>N-hexane</em> was the most active fraction followed by ethyl acetate when sucrose and maltose were used as substrates. The results suggest that the leaf fractions of <em>C. zambesicus </em>have the potentials to inhibit alpha amylase and glucosidase in rats.</p> ER -