ACTIVITIES OF FSH RECEPTORS ON THE RESTORATION OF REPRODUCTIVE INDICES IN HYPERPROLACTIN RATS TREATED WITH GREEN COCONUT WATER

Abstract

Background of the study: Green coconut water (GCW) exhibits fertility-enhancing properties. This study investigated the role of GCW on follicle stimulating hormone activation in understanding its mode of action.

Aim: We investigated the effect of GCW on the expression of FSH-receptors in the restoration of reproductive indices in hyperprolactin rats.

Material and Methods: Forty adult female Sprague-Dawley rats were randomized into four experimental study groups (A, B, C and D) of 10 rats each. The animals in group A received distilled water only. Group B, the positive control received GCW only, group C is the induction group and the animals received 5 mg/Kg B.W. metoclopramide. Group D is the post-treatment group and animals were treated with GCW following the experimental induction of hyperprolactinemia.

Result: The animals post-treated with GCW showed high expression level of FSH receptors at a molecular weight of 70 kDA that was comparable with the control and GCW-treated groups. However, low expression of the FSH receptors was seen in the induced group at a molecular weight of 10 kDA when compared with the control and GCW-treated groups. Additionally, there were comparable evaluations in the rate of pregnancy and number of foetuses in the animals post-treated with GCW and the control and GCW-treated groups. However the animals in the induced group recorded no pregnancy.

Conclusion: This study's outcome clearly depicts that GCW is an effective potential natural agent in the reversal of infertility caused by hyperprolactinemia through the activation of FSH receptors.