Electrolyte and renal status of HIV seropositive individuals on ART: a short-term follow-up study.

Authors

  • Onochie A.U Department of Biochemistry, Anambra State University, Uli, Anambra State, Nigeria.
  • Okaka A.N.C. Department of Applied Biochemistry, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Onyenekwe, C.C Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, PMB 5025, Awka, Anambra state, Nigeria.
  • Meludu, S.C Department of Human Biochemistry, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
  • Ezegwunne L.P Department of Human Biochemistry, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
  • Ifemeje, J.C Department of Biochemistry, Anambra State University of Science, Uli, Anambra State, Nigeria.

Keywords:

Infection, drugs, organs

Abstract

The study was designed to assess the renal and electrolyte status of HIV seropositive subjects during antiretroviral therapy follow up for 4 months. For this study, 20 HIV seropositive subjects were randomly recruited before commencement of anti-retroviral therapy and followed-up into 4 months of anti-retroviral therapy. Blood samples were collected before and bi-monthly during anti-retroviral therapy. The result of the present study showed that before anti-retroviral therapy, the serum levels of potassium and bicarbonate were the only electrolytes that showed significant increase compared with corresponding values in the control subjects (p<0.05 in each case). However, the serum concentrations of urea and creatinine were consistently raised in the HIV seropositive subjects before and during the ART compared with values observed in the control subjects (P<0.05 in each case). The findings of the present study suggest impaired kidney functions in HIV seropositive subjects with no immediate improvement within
4 months of ART.

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Published

17-12-2007

How to Cite

Onochie, A., Okaka, A., Onyenekwe, C., Meludu, S. C., Ezegwunne, L., & Ifemeje, J. (2007). Electrolyte and renal status of HIV seropositive individuals on ART: a short-term follow-up study . Journal of Biomedical Investigation, 5(2), 49–52. Retrieved from https://journals.unizik.edu.ng/jbi/article/view/2614

Issue

Vol. 5 No. 2 (2007)

Section

Articles

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