Evaluation of CD4°T CELL COUNT, Interleukin 6 (IL-6) and Interferon Gamma in HIV Infected Symptomatic and Asymptomatic Individuals

Authors

  • Ifeanyichukwu O.M. Department of Immunology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
  • Onyenekwe C.C Department of Chemical Pathology, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
  • Ele P.U Department of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
  • Ukibe N.K Department of Human Biochemistry, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
  • Meludu S.C Department of Human Biochemistry, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
  • Ezechukwu C.C Department of Immunology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
  • Okeregwo A.A Haematology and Immunology Department, University of Port Harcourt, College of Health Sciences, Port Harcourt, Rivers State, Nigeria.

Keywords:

cytokines, HIV, CD4

Abstract

The study was designed to assess the effect of HIV infection on CD4'T cell count, IL-6 and IFN-y in HIV infected individuals. Forty-five HIV positive subjects (male 27, female 18), aged between 15-65 years were recruited for the study. 21 of this (male 10, female=11) were HIV symptomatic individuals, while the remaining 24 subjects (male=17, female=7), were HIV asymptomatic individuals; 22 HIV seronegative subjects served as control individuals. Blood samples collected from all the individuals that participated in the study were used for the determination of HIV status by immunochromatographic method, CD4'T cell count by Flow Cytometry, IFN-y and IL-6 by ELISA method. The result showed diminished CD4'T cells count and serum concentration of IFN-y in HIV symptomatic individuals (P<0,.05 in each case). Meanwhile, the serum IL-6 concentration was similar amongst the three groups (p>0.1): The drop in both the CD4’T cell count and serum concentration of IFN-y in the HIV symptomatic individuals suggests possible progression in impairment of certain immunologic responses during HIV infection.

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Published

17-12-2007

How to Cite

Ifeanyichukwu, O., Onyenekwe, C., Ele, P., Ukibe, N., Meludu, S. C., Ezechukwu, C., & Okeregwo, A. (2007). Evaluation of CD4°T CELL COUNT, Interleukin 6 (IL-6) and Interferon Gamma in HIV Infected Symptomatic and Asymptomatic Individuals. Journal of Biomedical Investigation, 5(2), 70–73. Retrieved from https://journals.unizik.edu.ng/jbi/article/view/2619

Issue

Vol. 5 No. 2 (2007)

Section

Articles

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