COMPLETE BLOOD COUNT AND HORMONAL PARAMETERS IN SOME MENOPAUSAL WOMEN IN ILORIN, KWARA STATE. NIGERIA.

Abstract

Hormonal levels vary in women at different stages of life from puberty with remarkable observable changes from menopause. The purpose of this project was to carry out the complete blood count on Postmenopausal women with menstruating women who served as control and to assess selected hormonal parameters in Menopausal women and Premenopausal women through the measurement of the Follicle Stimulating Hormone and progesterone. A case (control) study involving postmenopausal and perimenopausal women conducted within Ilorin metropolis, Kwara state, Nigeria. The inclusion criteria was adult female subjects within age range from 18-65 years old. A standard venipuncture technique was used to collect blood sample in which 4ml was drawn aseptically from the vein using vacutainer tubes. The hormonal parameters was carried out using ab108678 follicle stimulating hormone and ab108670 progesterone human ELISA kit  following the standard operating procedure (SOP). The complete blood count CBC was carried out using the Sysmex1000i analyzer following the manufacturer’s instruction and using its reagent pack. The study found that at menopause the blood indices such as packed cell volume and lymphocyte increased while platelet and neutrophil levels were higher in premenopausal women. Haemoglobin concentration, total white blood cell count, and the mixed leucocyte parameters (Basophils, Monocytes, Eosinophils) were unaffected. The mean value of postmenopausal progesterone of the menopausal women increased in comparison with that of the pre-menopausal women. There was also a significant difference between the mean value of the postmenopausal FSH (follicle stimulating hormone) in menopausal level as compared with that of the premenopausal women. These findings indicate that the complete blood count and hormonal parameters are affected by menopause.