Toxicological studies of ethanol leaf extract of Lavandulastoechas on kidney of Wistar rat.

Abstract

The medicinal ingredients in herbal remedies are derived from plants. Despite the fact that they could offer a wide range of health advantages, they are thought to have a lower likelihood for adverse effects. The medicinal herb lavender (Lavandulastoechas L.) is widely utilized for a variety of medical conditions. The aim of this investigation is to evaluate the toxicological effect of Lavandulastoechas on Wistar rat kidney.Twenty four (24)Animals of either sex were used. Group 1 was given distilled water (10 ml/kg), while groups 2, 3, and 4 were given 50, 100, and 200 mg/kg of Lavandulastoechas, respectively for 28 days. Animals were housed in typical cages and given oral access to the extract for 28 days before being weighed and put to death. A heart puncture was used to get blood, which was then promptly taken for testing.Red blood cell, Hemoglobin, and Mean corpuscular volume levels decreased significantly (P<0.05), but neutrophils, basophiles, eosinophils, and platelets remained constant. At 100 and 200 mg/kg, Lavandulastoechas significantly (P<0.05)loweredK+ levels. Na+ increased significantly (P<0.05)at a dosage of 200 mg/kg. Across doses given, the levels of creatinine, chloride, and urea were not substantially (P<0.05)impacted. A histological analysis shows minimal tubular deformation.The study's findings indicated that the plant might have a negligible impact on the kidney, indicating that it should be used with caution if consumed over an extended period of time.